Article
Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism influences the susceptibility to gastric cancer in the Japanese population.
BMC gastroenterology - 13 Jan 2009
Shibata Tomoyuki, Arisawa Tomiyasu, Tahara Tomomitsu, Ohkubo Masaaki, Yoshioka Daisuke, Maruyama Naoko, Fujita Hiroshi, Kamiya Yoshio, Nakamura Masakatsu, Nagasaka Mitsuo, Iwata Masami, Takahama Kazuya, Watanabe Makoto, Hirata Ichiro
Abstract excerpt
BACKGROUND: Inflammation is a key factor in the process of carcinogenesis from chronic gastritis induced by Helicobacter pylori. Selenoprotein S (SEPS1) is involved in the control of the inflammatory response in the endoplasmic reticulum (ER). Recently the -105G>A polymorphism in the promoter of SEPS1 was shown to increase pro-inflammatory cytokine expression. We examined the association between this polymorphism...
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