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Article

The genetics of hereditary spastic paraplegia and implications for drug therapy.

Expert opinion on pharmacotherapy - 1 Jul 2007

Züchner Stephan

Abstract excerpt

Hereditary spastic paraplegia (HSP) comprises a group of clinically and genetically heterogeneous diseases that affect the upper motor neurons and their axonal projections. A total of 30 chromosomal loci have been identified for autosomal dominant, recessive and X-linked HSP. The underlying genes for 15 of these loci have been described. The molecular dissection of the cellular functions of the related gene...

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Identifiers

PMID: 17661726
DOI: 10.1517/14656566.8.10.1433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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