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Article

Hereditary spastic paraplegia: Genetic heterogeneity and common pathways.

Experimental neurology - 1 Nov 2022

Panza Emanuele, Meyyazhagan Arun, Orlacchio Antonio

Abstract excerpt

Hereditary Spastic Paraplegias (HSPs) are a heterogeneous group of disease, mainly characterized by progressive spasticity and weakness of the lower limbs resulting from distal degeneration of corticospinal tract axons. Although HSPs represent rare or ultra-rare conditions, with reported cases of mutated genes found in single families, overall, with 87 forms described, they are an important health and economic...

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Genetic Heterogeneity
Hereditary Neurological Disorders
Mutation
Neurogenetic and Muscular Disorders Research
Neurological diseases and metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pyramidal Tracts

Spastic Paraplegia, Hereditary

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PMID: 35970204
DOI: 10.1016/j.expneurol.2022.114203

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