Article

Investigating the molecular mechanisms of Hereditary Spastic Paraplegia neuropathies

2018-01-01

Abstract excerpt

Hereditary spastic paraplegia (HSP) was first described in the late 1800s and has since become a term used to describe this relatively large, clinically and genetically diverse group of inherited neurodegenerative or neurodevelopmental disorders. HSPs are characterised by progressive lower limb spasticity and pyramidal weakness, caused by genetic mutations. This defining clinical feature is thought to be due to th...

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Literature Corpus work: 13c85e28-f3c1-588b-a379-ecb1fffbbc81
DOI: 10.17638/03019569

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