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Article

Genetics of hereditary spastic paraplegias.

Seminars in neurology - 1 Nov 2011

Schüle Rebecca, Schöls Ludger

Abstract excerpt

Hereditary spastic paraplegias (HSPs) are clinically and genetically highly heterogeneous. The key symptom of spastic paraparesis of lower limbs can be complicated by a variety of signs and symptoms including cognitive impairment, optic atrophy, cerebellar ataxia, peripheral nerve involvement, or seizures. At least 48 loci have been identified, termed SPG1-SPG48. Ten genes for autosomal dominant HSP are currently...

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Source

Identifiers

PMID: 22266886
DOI: 10.1055/s-0031-1299787

Genes

SPG11
SPG7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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