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Article

Hereditary Spastic Paraplegia: An Update.

International journal of molecular sciences - 1 Feb 2022

Meyyazhagan Arun, Orlacchio Antonio

Abstract excerpt

Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disorder with the predominant clinical manifestation of spasticity in the lower extremities. HSP is categorised based on inheritance, the phenotypic characters, and the mode of molecular pathophysiology, with frequent degeneration in the axon of cervical and thoracic spinal cord's lateral region, comprising the corticospinal routes. The prevalence...

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Identifiers

PMID: 35163618
DOI: 10.3390/ijms23031697
PMCID: PMC8835766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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