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Article

Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Sept 2007

Yuan Jian-Min, Lu Shelly C, Van Den Berg David, Govindarajan Sugantha, Zhang Zhen-Quan, Mato Jose M, Yu Mimi C

Abstract excerpt

UNLABELLED: Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) are known to play a role in DNA methylation, synthesis, and repair. The genetic mutations in MTHFR and TYMS genes may have influences on their respective enzyme activities. Data on the association studies of the MTHFR and TYMS genetic polymorphisms and risk of hepatocellular carcinoma (HCC) are sparse. MTHFR and TYMS genotypes...

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Source

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Identifiers

PMID: 17659576
DOI: 10.1002/hep.21735
PMCID: PMC2391240

Genes

MTHFR
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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