Genetic variants in folate metabolism-related genes, serum folate and hepatocellular carcinoma survival: the Guangdong Liver Cancer Cohort study.

doi:10.1017/S0007114524001776

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Genetic variants in folate metabolism-related genes, serum folate and hepatocellular carcinoma survival: the Guangdong Liver Cancer Cohort study.

The British journal of nutrition - 14 Dec 2024

Li Yunshan, Shu Jing, Tan Peishan, Dong Xiaocong, Zhang Mingjie, He Tongtong, Yang Zhijun, Zhang Xuehong, Giovannucci Edward L, Liu Zhaoyan, Zhou Zhongguo, Li Qijiong, Xu Yanjun, Xu Xiaojun, Peng Tianyou, Lu Jialin, Zhang Yaojun, Zhu Huilian, Fang Aiping

Abstract excerpt

Folate metabolism is involved in the development and progression of various cancers. We investigated the association of single nucleotide polymorphisms (SNP) in folate-metabolising genes and their interactions with serum folate concentrations with overall survival (OS) and liver cancer-specific survival (LCSS) of newly diagnosed hepatocellular carcinoma (HCC) patients. We detected the genotypes of six SNP in...

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PMID: 39506332
DOI: 10.1017/S0007114524001776

Genes

MTRR
MTHFR
MTR

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