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Article

Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels.

Human genetics - 1 Sept 2002

Trinh Binh N, Ong Choon-Nam, Coetzee Gerhard A, Yu Mimi C, Laird Peter W

Abstract excerpt

The thymidylate synthase gene ( TYMS or TS) encodes a tightly regulated enzyme that catalyzes the conversion of deoxyuridylate to thymidylate, and contains a tandem repeat polymorphism that affects expression of the enzyme. We have investigated the relationship between TYMS genotype and plasma concentrations of homocysteine and folate in a cohort of 505 Chinese from Singapore. TYMS 3/3 genotype was associated...

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Source

Identifiers

PMID: 12215845
DOI: 10.1007/s00439-002-0779-2

Genes

TYMS
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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