Article
Genetic Polymorphism of MTHFR C677T Influences Susceptibility to HBV-Related Hepatocellular Carcinoma in a Chinese Population: a Case-Control Study.
Clinical laboratory - 1 Apr 2017
Qiao Kunyan, Zhang Shitian, Trieu Congdoanh, Dai Qinghai, Huo Zhixiao, Du Yanan, Lu Wei, Hou Wei
Abstract excerpt
BACKGROUND: Methylene tetrahydrofolate reductase (MTHFR) is the key enzyme of folic acid metabolism and the C677T mutation is associated with decreased enzyme activity. Several studies have shown its regulatory role in carcinogenesis and tumor growth. HBV (hepatitis B virus)-related HCC (hepatocellular carcinoma) is one of the most common liver cancers worldwide. Therefore, the present case-control study aimed to...
Topics
- Carcinoma, Hepatocellular
- Case-Control Studies
- Genetic Predisposition to Disease
- Genotype
- Hepatitis B
- Humans
- Liver Neoplasms
- Methylenetetrahydrofolate Reductase (NADPH2)
- Polymorphism, Genetic
- Risk Factors