Article
Microstructural White Matter Properties Mediate the Association between APOE and Perceptual Speed in Very Old Persons without Dementia.
PloS one - 1 Jan 2015
Laukka Erika J, Lövdén Martin, Kalpouzos Grégoria, Papenberg Goran, Keller Lina, Graff Caroline, Li Tie-Qiang, Fratiglioni Laura, Bäckman Lars
Abstract excerpt
BACKGROUND: Reduced white matter integrity, as indicated by lower fractional anisotropy (FA) and higher mean diffusivity (MD), has been related to poorer perceptual speed (PS) performance. As the ε4 allele has been associated with lower white matter integrity in old age, this represents a potential mechanism through which APOE may affect PS. OBJECTIVE: To examine whether the association between APOE and PS is...
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