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Article

Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation.

Experimental cell research - 10 Sept 2007

Knisely Jane M, Li Yonghe, Griffith Janice M, Geuze Hans J, Schwartz Alan L, Bu Guojun

Abstract excerpt

The LDL receptor-related protein 1B (LRP1B) is a putative tumor suppressor homologous to LRP1. Both LRP1 and LRP1B contain cytoplasmic tails with several potential endocytosis motifs. Although the positions of these endocytic motifs are similar in both receptors, LRP1B is internalized at a 15-fold slower rate than LRP1. To determine whether the slow endocytosis of LRP1B is due to the utilization of an endocytosis...

Topics

Amino Acid Sequence
Animals
CHO Cells
Cricetinae
Cricetulus
Cytoplasm
Endocytosis
Humans
Low Density Lipoprotein Receptor-Related Protein-1
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Conformation

Receptors, LDL

Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17658514
DOI: 10.1016/j.yexcr.2007.05.026
PMCID: PMC2002472

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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