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Article

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.

Journal of lipid research - 1 Jun 2012

Hong Cynthia, Bradley Michele N, Rong Xin, Wang Xuping, Wagner Alan, Grijalva Victor, Castellani Lawrence W, Salazar Jon, Realegeno Susan, Boyadjian Rima, Fogelman Alan M, Van Lenten Brian J, Reddy Srinivasa T, Lusis Aldons J, Tangirala Rajendra K, Tontonoz Peter

Abstract excerpt

The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRα, the dominant LXR isotype expressed in liver, plays a particularly important role in whole-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22454476
DOI: 10.1194/jlr.M022061
PMCID: PMC3351819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22454476-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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