Article
The plasminogen activator inhibitor-1 -675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: the HIFMECH study.
Journal of thrombosis and haemostasis : JTH - 1 Nov 2003
Juhan-Vague I, Morange P E, Frere C, Aillaud M F, Alessi M C, Hawe E, Boquist S, Tornvall P, Yudkin J S, Tremoli E, Margaglione M, Di Minno G, Hamsten A, Humphries S E
Abstract excerpt
UNLABELLED: Although the potential role of plasminogen activator inhibitor-1 (PAI-1) in the development of coronary artery disease is strongly supported by its biological characteristics, results of clinical studies remain controversial. OBJECTIVES: To investigate whether plasma PAI-1 concentrations and the -675 4G/5G polymorphism located in the PAI-1 gene could constitute risk markers for myocardial infarction...
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