Article
Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2007
Wu Chun-Te, Altuwaijri Saleh, Ricke William A, Huang Shu-Pin, Yeh Shuyuan, Zhang Caixia, Niu Yuanjie, Tsai Meng-Ying, Chang Chawnshang
Abstract excerpt
Developmental studies of the prostate have established that ductal morphogenesis, epithelial cytodifferentiation, and proliferation/apoptosis are regulated by androgens acting through stromal androgen receptor (AR). Here, we found mice lacking epithelial AR within the mature prostate (pes-ARKO) developed prostate tissue that was less differentiated and hyperproliferative relative to WT littermates. Epithelial AR...
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