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Article

Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing.

Nature communications - 23 Jan 2017

Xie Qing, Liu Yueli, Cai Tao, Horton Corrigan, Stefanson Joshua, Wang Zhu A

Abstract excerpt

Androgen signals through androgen receptor (AR) to influence prostate development and cancer. How stromal and epithelial AR regulate prostate homeostasis remains unclear. Using genetic lineage tracing, we systematically investigated the role of cell-autonomous AR in different prostate epithelial cell types. Here we show that AR is dispensable for basal cell maintenance, but is cell-autonomously required for the...

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Identifiers

PMID: 28112153
DOI: 10.1038/ncomms14284
PMCID: PMC5264212

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