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Article

Bipotent Progenitors Do Not Require Androgen Receptor for Luminal Specification during Prostate Organogenesis.

Stem cell reports - 10 Nov 2020

Shibata Maho, Epsi Nusrat J, Xuan Shouhong, Mitrofanova Antonina, Shen Michael M

Abstract excerpt

Androgen receptor (AR) plays a fundamental role in most aspects of adult prostate homeostasis, and anti-androgen therapy represents the cornerstone of prostate cancer treatment. However, early prostate organogenesis takes place during pre-pubertal stages when androgen levels are low, raising the possibility that AR function is more limited during prostate development. Here, we use inducible AR deletion and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33176121
DOI: 10.1016/j.stemcr.2020.10.004
PMCID: PMC7664048

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