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Article

Androgen sensitivity of prostate epithelium is enhanced by postnatal androgen receptor inactivation.

American journal of physiology. Endocrinology and metabolism - 1 Jun 2009

Simanainen Ulla, McNamara Keely, Gao Yan Ru, Handelsman David J

Abstract excerpt

Postnatal inactivation of epithelial androgen receptor (AR) in prostate epithelial AR knockout (PEARKO) mice results in hindered differentiation but enhanced proliferation of epithelial cells. As this resembles the precancerous proliferative atrophy of human prostates with undifferentiated but intensively replicating epithelial cells, we utilized the PEARKO mice to characterize the epithelial response to...

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Identifiers

PMID: 19366880
DOI: 10.1152/ajpendo.00017.2009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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