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Article

Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function.

Endocrinology - 1 May 2007

Simanainen Ulla, Allan Charles M, Lim Patrick, McPherson Stephen, Jimenez Mark, Zajac Jeffrey D, Davey Rachel A, Handelsman David J

Abstract excerpt

Prostate development and maturation requires stromal-epithelial interactions and androgen action via the androgen receptor (AR) within these compartments. However, the specific roles of epithelial and stromal AR in postnatal prostate differentiation are unclear. We used Cre-LoxP technology to determine the prostate phenotype in mice with epithelial-selective genetic inactivation of the AR leaving the stromal AR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17317769
DOI: 10.1210/en.2006-1223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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