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Article

Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor.

Cancer research - 1 Aug 2007

Funahashi Hitoshi, Satake Makoto, Dawson David, Huynh Ngoc-An, Reber Howard A, Hines Oscar J, Eibl Guido

Abstract excerpt

Pancreatic ductal adenocarcinomas are thought to arise from noninvasive, intraductal precursor lesions called pancreatic intraepithelial neoplasias (PanIN). The study of PanINs holds great promise for the identification of early detection markers and effective cancer-preventing strategies. Cyclooxygenase-2 (COX-2) represents an intriguing target for therapeutic and preventive approaches in various human...

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Source

Identifiers

PMID: 17652141
DOI: 10.1158/0008-5472.CAN-07-0970

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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