Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D/+ mice.

International journal of cancer - 15 Oct 2012

Mohammed Altaf, Qian Li, Janakiram Naveena B, Lightfoot Stan, Steele Vernon E, Rao Chinthalapally V

Abstract excerpt

Pancreatic cancer is the one of most common causes of cancer deaths and has the worst prognosis. Clinical observational studies suggest that statins may reduce the risk of pancreatic cancer. The chemopreventive efficacy of the statin atorvastatin (Lipitor(®)) and the role of the phosphatidyl-inositol 3-kinase (PI3/AKT) signaling pathway were evaluated for the progression of pancreatic intraepithelial neoplasms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atorvastatin
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique

Share to Heptanoic Acids

Share to Immunoenzyme Techniques

Share to Integrases

Share to Proto-Oncogene Proteins c-akt

Share to Pyrroles

Source

Open in PubMed Open full text

Identifiers

PMID: 22287227
DOI: 10.1002/ijc.27456
PMCID: PMC3376252

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D/+ mice.PMID 22287227Read ↗

Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras.Semantic proximity Read ↗

Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice.Semantic proximity Read ↗

Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E δ-tocotrienol.Semantic proximity Read ↗

Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway.Semantic proximity Read ↗

Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEBSemantic proximity Read ↗

High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model.Semantic proximity Read ↗

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.Semantic proximity Read ↗

Chemoprevention and Treatment of Pancreatic Cancer: Update and Review of the Literature.Semantic proximity Read ↗

Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor.Semantic proximity Read ↗

PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer.Semantic proximity Read ↗

Meat enriched-diet and inflammation promote PI3Kα-dependent pancreatic cell plasticity that limit tissue regenerationSemantic proximity Read ↗

Low-dose simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEBSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.