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Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E δ-tocotrienol.

Carcinogenesis - 1 Apr 2013

Husain Kazim, Centeno Barbara A, Chen Dung-Tsa, Fulp William J, Perez Marta, Zhang Lee Guo, Luetteke Noreen, Hingorani Sunil R, Sebti Said M, Malafa Mokenge P

Abstract excerpt

The highly lethal nature of pancreatic cancer and the increasing recognition of high-risk individuals have made research into chemoprevention a high priority. Here, we tested the chemopreventive activity of δ-tocotrienol, a bioactive vitamin E derivative extracted from palm fruit, in the LSL-Kras(G12D/+);Pdx-1-Cre pancreatic cancer mouse model. At 10 weeks of age, mice (n = 92) were randomly allocated to three...

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Identifiers

PMID: 23302291
DOI: 10.1093/carcin/bgt002
PMCID: PMC3616675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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