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Article

Phenotypic characterization of nonsocial behavioral impairment in neurexin 1α knockout rats.

Behavioral neuroscience - 1 Feb 2015

Esclassan Frederic, Francois Jennifer, Phillips Keith G, Loomis Sally, Gilmour Gary

Abstract excerpt

Neurexins are neuronal presynaptic proteins that play a key role in mediation of synapse formation. Heterozygous partial deletions in the neurexin-1 gene (NRXN1, 2p16.3) have been observed in autism spectrum disorder (ASD) patients. NRXN1-α knockout (KO) mice present behavioral impairments that resemble some of the core ASD symptoms of social impairment and inflexibility/stereotypy. At present, a thorough...

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Source

Identifiers

PMID: 25420124
DOI: 10.1037/bne0000024

Genes

NRXN1

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