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Article

Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse.

PloS one - 1 Jan 2012

Kielar Catherine, Sawiak Stephen J, Navarro Negredo Paloma, Tse Desmond H Y, Morton A Jennifer

Abstract excerpt

Complexins (Cplxs) are small, soluble, regulatory proteins that bind reversibly to the SNARE complex and modulate synaptic vesicle release. Cplx1 knockout mice (Cplx1(-/-)) have the earliest known onset of ataxia seen in a mouse model, although hitherto no histopathology has been described in these mice. Nevertheless, the profound neurological phenotype displayed by Cplx1(-/-) mutants suggests that significant...

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Identifiers

PMID: 22393426
DOI: 10.1371/journal.pone.0032636
PMCID: PMC3290572

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Source receipt: pubmed, retrieved 7 Sept 2026.

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