Article
Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant mice.
PloS one - 1 Jan 2012
Distler Margaret G, Opal Mark D, Dulawa Stephanie C, Palmer Abraham A
Abstract excerpt
Schizophrenia is a debilitating psychotic disorder that affects up to 1.5% of the population worldwide. Two recent studies in humans identified genome-wide significant associations between schizophrenia and single-nucleotide polymorphisms (SNPs) in an intron of CSMD1. The effect of deleting CSMD1 on mouse behavior is unknown. The present study utilized mice with a mutant Csmd1 allele in which the first exon had...
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