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Article

Changes in object recognition and anxiety-like behaviour in mice expressing a Cx47 mutation that causes Pelizaeus-Merzbacher-like disease.

Developmental neuroscience - 1 Jan 2012

Zlomuzica Armin, Tress Oliver, Binder Sonja, Rovira Catherine, Willecke Klaus, Dere Ekrem

Abstract excerpt

Pelizaeus-Merzbacher-like disease is characterized by impaired psychomotor development, ataxia, progressive spasticity and mental retardation. It is induced by mutations in the gap junction gene GJC2 that encodes for the gap junction protein connexin 47. Mice bearing a human Cx47M283T missense mutation have been generated as a transgenic mouse model of Pelizaeus-Merzbacher-like disease. Homozygous expression of...

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Source

Identifiers

PMID: 22832166
DOI: 10.1159/000339305

Genes

GJC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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