Article
Sumoylation in axons triggers retrograde transport of the RNA-binding protein La.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2007
van Niekerk Erna A, Willis Dianna E, Chang Jay H, Reumann Kerstin, Heise Tilman, Twiss Jeffery L
Abstract excerpt
A surprisingly large population of mRNAs has been shown to localize to sensory axons, but few RNA-binding proteins have been detected in these axons. These axonal mRNAs include several potential binding targets for the La RNA chaperone protein. La is transported into axonal processes in both culture and peripheral nerve. Interestingly, La is posttranslationally modified in sensory neurons by sumoylation. In...
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