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Article

Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis.

Blood - 9 Jul 2009

Skuli Nicolas, Liu Liping, Runge Anja, Wang Tao, Yuan Lijun, Patel Sunny, Iruela-Arispe Luisa, Simon M Celeste, Keith Brian

Abstract excerpt

Hypoxia-inducible factor-2alpha (HIF-2alpha) is highly expressed in embryonic vascular endothelial cells (ECs) and activates the expression of target genes whose products modulate vascular function and angiogenesis. In this report, we describe a genetic model designed to test the physiologic cons...

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Share to Basic Helix-Loop-Helix Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

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Source

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Identifiers

PMID: 19439736
DOI: 10.1182/blood-2008-12-193581
PMCID: PMC2714217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19439736-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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