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Article

Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection.

Nature immunology - 1 Dec 2004

Zuniga Elina I, McGavern Dorian B, Pruneda-Paz Jose L, Teng Chao, Oldstone Michael B A

Abstract excerpt

Two subsets of dendritic cell (DCs), plasmacytoid (p) and myeloid (m) DCs, have been described in humans and mice. These subsets are known to have divergent roles during an immune response, but their developmental course is unclear. Here we report that virus infection induces bone marrow pDCs to differentiate into mDCs, thereby undergoing profound phenotypic and functional changes including the acquisition of...

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Identifiers

PMID: 15531885
DOI: 10.1038/ni1136
PMCID: PMC5340300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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