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Article

Allele-specific polymerase chain reaction diagnostic test for the functional MDR1 polymorphism in dogs.

Veterinary journal (London, England : 1997) - 1 Sept 2008

Baars Cordula, Leeb Tosso, von Klopmann Thilo, Tipold Andrea, Potschka Heidrun

Abstract excerpt

The major multidrug transporter P-glycoprotein (Pgp) contributes to the barrier function of several tissues and organs, including the brain. In a subpopulation of Collies and seven further dog breeds, a 4 base pair deletion has been described in the Pgp-encoding MDR1 gene. This deletion results in the absence of a functional form of Pgp and loss of its protective function. Severe intoxication with the Pgp...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Breeding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MDR

Share to Ivermectin

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Share to Polymorphism, Genetic

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 17644437
DOI: 10.1016/j.tvjl.2007.05.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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