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Article

Evolutionarily conserved E(y)2/Sus1 protein is essential for the barrier activity of Su(Hw)-dependent insulators in Drosophila.

Molecular cell - 20 Jul 2007

Kurshakova Maria, Maksimenko Oksana, Golovnin Anton, Pulina Maria, Georgieva Sofia, Georgiev Pavel, Krasnov Aleksey

Abstract excerpt

Chromatin insulators affect interactions between promoters and enhancers/silencers and function as barriers for spreading of repressive chromatin. The Su(Hw) protein is responsible for activity of the best-studied Drosophila insulators. Here we demonstrate that an evolutionarily conserved protein, E(y)2/Sus1, is recruited to the Su(Hw) insulators via binding to the zinc-finger domain of Su(Hw). Partial...

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PMID: 17643381
DOI: 10.1016/j.molcel.2007.05.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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