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Article

MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA

1 Jan 2013

Abstract excerpt

Maintenance of genetic stability is crucial for all organisms in order to avoid the onset of deleterious diseases such as cancer. One of the many proveniences of DNA base damage in mammalian cells is oxidative stress, arising from a variety of endogenous and exogenous sources, generating highly mutagenic oxidative DNA lesions. One of the best characterized oxidative DNA lesion is 7,8-dihydro-8-oxoguanine...

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Identifiers

PMID: 23450852
DOI: 10.3389/fgene.2013.00018

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