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Article

Role of MUTYH in human cancer.

Mutation research - 1 Jan 2000

Mazzei Filomena, Viel Alessandra, Bignami Margherita

Abstract excerpt

MUTYH, a human ortholog of MutY, is a post-replicative DNA glycosylase, highly conserved throughout evolution, involved in the correction of mismatches resulting from a faulty replication of the oxidized base 8-hydroxyguanine (8-oxodG). In particular removal of adenine from A:8-oxodG mispairs by MUTYH activity is followed by error-free base excision repair (BER) events, leading to the formation of C:8-oxodG base...

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Source

Identifiers

PMID: 23507534
DOI: 10.1016/j.mrfmmm.2013.03.003

Genes

MUTYH
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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