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Article

GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability.

Molecular and cellular biology - 1 Sept 2007

Knezevic Nebojsa, Roy Arun, Timblin Barbara, Konstantoulaki Maria, Sharma Tiffany, Malik Asrar B, Mehta Dolly

Abstract excerpt

We identified the GDI-1-regulated mechanism of RhoA activation from the Rho-GDI-1 complex and its role in mediating increased endothelial permeability. Thrombin stimulation failed to induce RhoA activation and actin stress fiber formation in human pulmonary arterial endothelial cells transduced with full-length GDI-1. Expression of a GDI-1 mutant form (C-GDI) containing the C terminus (aa 69 to 204) also...

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Source

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Identifiers

PMID: 17636025
DOI: 10.1128/MCB.00523-07
PMCID: PMC2099605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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