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Article

Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA.

American journal of physiology. Cell physiology - 1 Nov 2008

Qiao Jing, Holian Oksana, Lee Bao-Shiang, Huang Fei, Zhang Jihang, Lum Hazel

Abstract excerpt

The cAMP-PKA cascade is a recognized signaling pathway important in inhibition of inflammatory injury events such as endothelial permeability and leucocyte trafficking, and a critical target of regulation is believed to be inhibition of Rho proteins. Here, we hypothesize that PKA directly phosphorylates GTP dissociation inhibitor (GDI) to negatively regulate Rho activity. Amino acid analysis of GDIalpha showed...

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Identifiers

PMID: 18768928
DOI: 10.1152/ajpcell.00139.2008
PMCID: PMC2584978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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