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Article

Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes.

Small GTPases - 2 Apr 2016

Auguste David, Maier Mirela, Baldwin Cindy, Aoudjit Lamine, Robins Richard, Gupta Indra R, Takano Tomoko

Abstract excerpt

Nephrotic syndrome (NS) describes a group of kidney disorders in which there is injury to podocyte cells, specialized cells within the kidney's glomerular filtration barrier, allowing proteins to leak into the urine. Three mutations in ARHGDIA, which encodes Rho GDP dissociation inhibitor α (GDIα), have been reported in patients with heritable NS and encode the following amino acid changes: ΔD185, R120X, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26726844
DOI: 10.1080/21541248.2015.1113353
PMCID: PMC4905261

Genes

ARHGDIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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