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Article

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2013

Subramanian H, Zahedi R P, Sickmann A, Walter U, Gambaryan S

Abstract excerpt

BACKGROUND: Signaling via protein kinase A (PKA) and protein kinase G (PKG) is critical for maintaining platelets in the resting state. Both kinases down-regulate the activity of the small GTPase Rap1b, a critical signaling switch for integrin activation and platelet aggregation. However, the mechanism of Rap1b regulation by PKA and PKG is largely unknown. OBJECTIVE: To identify the PKA phosphorylation sites in...

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Identifiers

PMID: 23611601
DOI: 10.1111/jth.12271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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