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Article

Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone

2 Nov 2015

Abstract excerpt

The group A Streptococcus (GAS) M1T1 clone emerged in the 1980s as a leading cause of epidemic invasive infections worldwide, including necrotizing fasciitis and toxic shock syndrome. Horizontal transfer of mobile genetic elements has played a central role in the evolution of the M1T1 clone, with bacteriophage-encoded determinants DNase Sda1 and superantigen SpeA2 contributing to enhanced virulence and...

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PMID: 26522788
DOI: 10.1038/srep15877

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