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Article

An avian influenza H5N1 virus that binds to a human-type receptor.

Journal of virology - 1 Sept 2007

Auewarakul Prasert, Suptawiwat Ornpreya, Kongchanagul Alita, Sangma Chak, Suzuki Yasuo, Ungchusak Kumnuan, Louisirirotchanakul Suda, Lerdsamran Hatairat, Pooruk Phisanu, Thitithanyanont Arunee, Pittayawonganon Chakrarat, Guo Chao-Tan, Hiramatsu Hiroaki, Jampangern Wipawee, Chunsutthiwat Supamit, Puthavathana Pilaipan

Abstract excerpt

Avian influenza viruses preferentially recognize sialosugar chains terminating in sialic acid-alpha2,3-galactose (SAalpha2,3Gal), whereas human influenza viruses preferentially recognize SAalpha2,6Gal. A conversion to SAalpha2,6Gal specificity is believed to be one of the changes required for the introduction of new hemagglutinin (HA) subtypes to the human population, which can lead to pandemics. Avian influenza...

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Identifiers

PMID: 17626098
DOI: 10.1128/JVI.00468-07
PMCID: PMC2045398

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