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Article

Characterization of H5N1 influenza virus variants with hemagglutinin mutations isolated from patients.

mBio - 7 Apr 2015

Watanabe Yohei, Arai Yasuha, Daidoji Tomo, Kawashita Norihito, Ibrahim Madiha S, El-Gendy Emad El-Din M, Hiramatsu Hiroaki, Kubota-Koketsu Ritsuko, Takagi Tatsuya, Murata Takeomi, Takahashi Kazuo, Okuno Yoshinobu, Nakaya Takaaki, Suzuki Yasuo, Ikuta Kazuyoshi

Abstract excerpt

UNLABELLED: A change in viral hemagglutinin (HA) receptor binding specificity from α2,3- to α2,6-linked sialic acid is necessary for highly pathogenic avian influenza (AI) virus subtype H5N1 to become pandemic. However, details of the human-adaptive change in the H5N1 virus remain unknown. Our database search of H5N1 clade 2.2.1 viruses circulating in Egypt identified multiple HA mutations that had been selected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

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Identifiers

PMID: 25852160
DOI: 10.1128/mBio.00081-15
PMCID: PMC4453573

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