Article
Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin.
PLoS pathogens - 1 Aug 2020
Du Wenjuan, Wolfert Margreet A, Peeters Ben, van Kuppeveld Frank J M, Boons Geert-Jan, de Vries Erik, de Haan Cornelis A M
Abstract excerpt
Influenza A viruses (IAVs) cause seasonal epidemics and occasional pandemics. Most pandemics occurred upon adaptation of avian IAVs to humans. This adaptation includes a hallmark receptor-binding specificity switch of hemagglutinin (HA) from avian-type α2,3- to human-type α2,6-linked sialic acids. Complementary changes of the receptor-destroying neuraminidase (NA) are considered to restore the precarious, but...
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