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Article

Residue Y161 of influenza virus hemagglutinin is involved in viral recognition of sialylated complexes from different hosts.

Journal of virology - 1 Apr 2012

Wang Minxiu, Tscherne Donna M, McCullough Christopher, Caffrey Michael, García-Sastre Adolfo, Rong Lijun

Abstract excerpt

Influenza A virus glycoprotein hemagglutinin (HA) binds to host cell surface sialic acid (SA)-terminated sugars in glycoproteins to initiate viral entry. It is thought that avian influenza viruses preferentially bind to N-acetylneuraminic acid α3 (NeuAcα3) sugars, while human influenza viruses exhibit a preference for NeuAcα6-containing sugars. Thus, species-specific SA(s) is one of the determinants in viral host...

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Identifiers

PMID: 22301136
DOI: 10.1128/JVI.07187-11
PMCID: PMC3318606

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