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Article

TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF.

PLoS genetics - 1 Mar 2017

Seberg Hannah E, Van Otterloo Eric, Loftus Stacie K, Liu Huan, Bonde Greg, Sompallae Ramakrishna, Gildea Derek E, Santana Juan F, Manak J Robert, Pavan William J, Williams Trevor, Cornell Robert A

Abstract excerpt

Mutations in the gene encoding transcription factor TFAP2A result in pigmentation anomalies in model organisms and premature hair graying in humans. However, the pleiotropic functions of TFAP2A and its redundantly-acting paralogs have made the precise contribution of TFAP2-type activity to melanocyte differentiation unclear. Defining this contribution may help to explain why TFAP2A expression is reduced in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microphthalmia-Associated Transcription Factor

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Source

Open in PubMed Open full text

Identifiers

PMID: 28249010
DOI: 10.1371/journal.pgen.1006636
PMCID: PMC5352137

Genes

MITF
TRPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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