Article
Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.
Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2010
Lacroix Matthieu, Caramel Julie, Goguet-Rubio Perrine, Linares Laetitia K, Estrach Soline, Hatchi Elodie, Rodier Geneviève, Lledo Gwendaline, de Bettignies Carine, Thépot Amélie, Deraison Céline, Chébli Karim, Hovnanian Alain, Hainaut Pierre, Dubus Pierre, Sardet Claude, Le Cam Laurent
Abstract excerpt
A growing body of evidence suggests that the multifunctional protein E4F1 is involved in signaling pathways that play essential roles during normal development and tumorigenesis. We generated E4F1 conditional knockout mice to address E4F1 functions in vivo in newborn and adult skin. E4F1 inactivation in the entire skin or in the basal compartment of the epidermis induces skin homeostasis defects, as evidenced by...
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