SNP rs16906252C>T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer.

doi:10.1158/1078-0432.CCR-15-2765

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Article

SNP rs16906252C>T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2016

Kuroiwa-Trzmielina Joice, Wang Fan, Rapkins Robert W, Ward Robyn L, Buchanan Daniel D, Win Aung Ko, Clendenning Mark, Rosty Christophe, Southey Melissa C, Winship Ingrid M, Hopper John L, Jenkins Mark A, Olivier Jake, Hawkins Nicholas J, Hitchins Megan P

Abstract excerpt

PURPOSE: Methylation of the MGMT promoter is the major cause of O6-methylguanine methyltransferase deficiency in cancer and has been associated with the T variant of the promoter enhancer SNP rs16906252C>T. We sought evidence for an association between the rs16906252C>T genotype and increased risk of developing a subtype of colorectal cancer featuring MGMT methylation, mediated by genotype-dependent epigenetic...

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Identifiers

PMID: 27267851
DOI: 10.1158/1078-0432.CCR-15-2765
PMCID: PMC5143212

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SNP rs16906252C>T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer.PMID 27267851Read ↗

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