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Article

Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice.

The American journal of pathology - 1 Aug 2007

Suzuki Sayuri, Fukasawa Hirotaka, Kitagawa Kyoko, Uchida Chiharu, Hattori Takayuki, Isobe Tomoyasu, Oda Toshiaki, Misaki Taro, Ohashi Naro, Nakayama Keiko, Nakayama Keiichi I, Hishida Akira, Yamamoto Tatsuo, Kitagawa Masatoshi

Abstract excerpt

Ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27 mediated by SCF-Skp2 ubiquitin ligase is involved in cell cycle regulation. Proliferation of tubular cells is a characteristic feature in obstructed kidneys of unilateral ureteral obstruction. Comparing Skp2(+/+) mice wi...

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Source

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Identifiers

PMID: 17620370
DOI: 10.2353/ajpath.2007.070279
PMCID: PMC1934544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17620370-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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