Article
Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2003
Drobnjak Marija, Melamed Jonathan, Taneja Samir, Melzer Kate, Wieczorek Rosemary, Levinson Benjamin, Zeleniuch-Jacquotte Anne, Polsky David, Ferrara Jay, Perez-Soler Roman, Cordon-Cardo Carlos, Pagano Michele, Osman Iman
Abstract excerpt
PURPOSE: The purpose is to investigate the clinical relevance of altered patterns of p27 and Skp2 expression in African-American patients with localized prostate cancer. The abundance of p27, an inhibitor of cell proliferation, is controlled by Skp2-dependent proteolysis. EXPERIMENTAL DESIGN: A well-characterized cohort of 162 African-Americans who underwent radical prostatectomy at the Veterans Affairs Medical...
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