Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prognostic implication of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma: a tissue microarray study

15 Oct 2008

Abstract excerpt

BACKGROUND: p27Kip1 plays a major role as a negative regulator of the cell cycle. The regulation of p27Kip1 degradation is mediated by its specific ubiquitin ligase subunits S-phase kinase protein (Skp) 2 and cyclin-dependent kinase subunit (Cks) 1. However, little is known regarding the prognostic utility of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma. METHODS: Immunohistochemistry was performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Renal cell carcinoma treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18922157
DOI: 10.1186/1756-9966-27-51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Prognostic implication of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma: a tissue microarray studyPMID 18922157Read ↗

The expression of the ubiquitin ligase subunit Cks1 in human breast cancerSemantic proximity Read ↗

Clinical significance and expression of cyclin kinase subunits 1 and 2 in hepatocellular carcinomaSemantic proximity Read ↗

Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients.Semantic proximity Read ↗

Skp2 overexpression is a p27<sup>Kip1</sup>‐independent predictor of poor prognosis in patients with biliary tract cancersSemantic proximity Read ↗

P53 mutations and other prognostic factors of renal cell carcinoma.Semantic proximity Read ↗

Skp2 is oncogenic and overexpressed in human cancersSemantic proximity Read ↗

p27kip1: a target for tumor therapies?Semantic proximity Read ↗

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancerSemantic proximity Read ↗

Expression of cyclins A and D and p21(waf1/cip1) proteins in renal cell cancer and their relation to clinicopathological variables and patient survivalSemantic proximity Read ↗

Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice.Semantic proximity Read ↗

Skp2 Protein Expression in Soft Tissue SarcomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.