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Article

Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.

Kidney international - 1 Jun 2016

Lu Dongmei, Rauhauser Alysha, Li Binghua, Ren Chongyu, McEnery Kayla, Zhu Jili, Chaki Moumita, Vadnagara Komal, Elhadi Sarah, Jetten Anton M, Igarashi Peter, Attanasio Massimo

Abstract excerpt

Enlargement of kidney tubules is a common feature of multiple cystic kidney diseases in humans and mice. However, while some of these pathologies are characterized by cyst expansion and organ enlargement, in others, progressive interstitial fibrosis and kidney atrophy prevail. The Kif3a knockout mouse is an established non-orthologous mouse model of cystic kidney disease. Conditional inactivation of Kif3a in...

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Identifiers

PMID: 27181777
DOI: 10.1016/j.kint.2016.03.006
PMCID: PMC5584074

Genes

GLIS2

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.PMID 27181777Read ↗

Inactivation of <i>Nphp2</i> in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouseSemantic proximity Read ↗

Renal Tubule-Specific Deletion of Nephrocystin 3 (Nphp3) Causes Infantile Nephronophthisis-like Phenotypes in Mice.Semantic proximity Read ↗

Inactivation of Invs/Nphp2 in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouse.Semantic proximity Read ↗

Glis3 is a modifier of cyst progression in autosomal dominant polycystic kidney diseaseSemantic proximity Read ↗

Innate Immune Signaling Contributes to Tubular Cell Senescence in the Glis2 Knockout Mouse Model of NephronophthisisSemantic proximity Read ↗

NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.Semantic proximity Read ↗

YAP restricts renal inflammation and mitigates kidney damage in nephronothisis related kidney diseaseSemantic proximity Read ↗

Developmental switch dichotomizes kidney response to <i>Nphp3</i> inactivation and treatment outcomeSemantic proximity Read ↗

Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis.Semantic proximity Read ↗

Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney diseaseSemantic proximity Read ↗

The nephronophthisis protein <i>GLIS2</i> / <i>NPHP7</i> is required for the DNA damage response in kidney tubular epithelial cellsSemantic proximity Read ↗

Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions.Semantic proximity Read ↗

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