Article
The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease.
International journal of cancer - 1 Mar 2010
Calvisi Diego F, Pinna Federico, Ladu Sara, Muroni Maria R, Frau Maddalena, Demartis Ilaria, Tomasi Maria L, Sini Marcella, Simile Maria M, Seddaiu Maria A, Feo Francesco, Pascale Rosa M
Abstract excerpt
Previous work showed a genetic control of cell cycle deregulation during hepatocarcinogenesis. We now evaluated in preneoplastic lesions, dysplastic nodules and hepatocellular carcinoma (HCC), chemically induced in genetically susceptible F344 and resistant Brown Norway (BN) rats, the role of cell cycle regulating proteins in the determination of a phenotype susceptible to HCC development. p21(WAF1), p27(KIP1),...
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